diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index f252589..d70e3a5 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -31,6 +31,12 @@ jobs:
       run: |
         clang main.c -o ruapu-clang
         ./ruapu-clang
+    - name: build-test-python
+      run: |
+        python3 -m pip install pip -U
+        python3 -m pip install setuptools -U
+        pip3 install .
+        python3 -c 'import ruapu; print(ruapu.supports("neon")); print(ruapu.supports(isa="avx"))'
 
   macos:
     runs-on: macos-latest
@@ -40,6 +46,12 @@ jobs:
       run: |
         clang main.c -o ruapu
         ./ruapu
+    - name: build-test-python
+      run: |
+        python3 -m pip install pip -U
+        python3 -m pip install setuptools -U
+        pip3 install .
+        python3 -c 'import ruapu; print(ruapu.supports("neon")); print(ruapu.supports(isa="avx"))'
 
   macos-arm64:
     runs-on: macos-14
@@ -49,6 +61,12 @@ jobs:
       run: |
         clang main.c -o ruapu
         ./ruapu
+    - name: build-test-python
+      run: |
+        python3 -m pip install pip -U
+        python3 -m pip install setuptools -U
+        pip3 install .
+        python3 -c 'import ruapu; print(ruapu.supports("neon")); print(ruapu.supports(isa="avx"))'
 
   windows:
     runs-on: windows-latest
@@ -64,6 +82,12 @@ jobs:
       run: |
         gcc main.c -o ruapu-mingw.exe
         ./ruapu-mingw.exe
+    - name: build-test-python
+      run: |
+        python3 -m pip install pip -U
+        python3 -m pip install setuptools -U
+        pip3 install .
+        python3 -c 'import ruapu; print(ruapu.supports("neon")); print(ruapu.supports(isa="avx"))'
 
   qemu:
     runs-on: ubuntu-latest
diff --git a/.gitignore b/.gitignore
new file mode 100644
index 0000000..b07d6d1
--- /dev/null
+++ b/.gitignore
@@ -0,0 +1,5 @@
+# Python files
+build/
+dist/
+*.egg-info/
+*.pyc
diff --git a/README.md b/README.md
index 72c8f2a..6a705e3 100644
--- a/README.md
+++ b/README.md
@@ -37,6 +37,8 @@ int main()
 
 ## Let's ruapu
 
+### ruapu with C
+
 <table>
 
 <tr><td>
@@ -77,6 +79,35 @@ xop = 0
 </td></tr>
 </table>
 
+### ruapu with Python
+
+<table>
+
+<tr><td>
+
+Compile and install ruapu library
+
+```shell
+# from source code
+pip3 install .
+```
+</td>
+<td>
+
+Use ruapu in python
+
+```shell
+$ python3
+>>> import ruapu
+>>> ruapu.supports("avx2")
+True
+>>> ruapu.supports(isa="avx2")
+True
+...
+```
+</td></tr>
+</table>
+
 <details>
 <summary>Github-hosted runner result (Linux)</summary>
 
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..482069a
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,25 @@
+[build-system]
+requires = ["setuptools", "cython"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "ruapu"
+authors = [
+    {name = "nihui", email = "shuizhuyuanluo@126.com"},
+    {name = "cocoa-xu", email = "i@uwucocoa.moe"},
+]
+description = "The Python binding of ruapu."
+readme = "README.md"
+requires-python = ">=3.5"
+keywords = ["ruapu", "cpu", "isa", "detect"]
+license = {"text" = "MIT"}
+version = "0.1.0"
+
+[project.urls]
+"Homepage" = "https://github.com/nihui/ruapu"
+
+[tool.setuptools]
+package-dir = {"" = "."}
+
+[tool.setuptools.packages.find]
+where = ["."]
diff --git a/ruapu-py.c b/ruapu-py.c
new file mode 100644
index 0000000..c6ca524
--- /dev/null
+++ b/ruapu-py.c
@@ -0,0 +1,37 @@
+#define PY_SSIZE_T_CLEAN
+#include <Python.h>
+
+#define RUAPU_IMPLEMENTATION
+#include "ruapu.h"
+
+static PyObject *ruapu_supports_py(PyObject *self, PyObject *args, PyObject *kwargs)
+{
+    static char *kwlist[] = {"isa", NULL};
+    const char *isa;
+    if (!PyArg_ParseTupleAndKeywords(args, kwargs, "s", kwlist, &isa))
+        return NULL;
+    if (ruapu_supports(isa))
+        Py_RETURN_TRUE;
+    Py_RETURN_FALSE;
+}
+
+static PyMethodDef ruapu_methods[] =
+{
+    {"supports", ruapu_supports_py, METH_VARARGS | METH_KEYWORDS, "Check if the CPU supports an instruction set"},
+    {NULL, NULL, 0, NULL}
+};
+
+static struct PyModuleDef ruapu_module =
+{
+    PyModuleDef_HEAD_INIT,
+    "ruapu",
+    "ruapu module",
+    -1,
+    ruapu_methods
+};
+
+PyMODINIT_FUNC PyInit_ruapu(void)
+{
+    ruapu_init();
+    return PyModule_Create(&ruapu_module);
+}
diff --git a/setup.py b/setup.py
new file mode 100644
index 0000000..fb88143
--- /dev/null
+++ b/setup.py
@@ -0,0 +1,18 @@
+#!/usr/bin/env python3
+# -*- coding: utf-8 -*-
+
+from setuptools import setup, find_packages, Extension
+
+ext = Extension(
+    name                = 'ruapu',
+    sources             = ['ruapu-py.c'],
+    py_limited_api      = True
+)
+
+setup_args = dict(
+    packages        = find_packages(where="."),
+    package_dir     = {"": "."},
+    ext_modules     = [ext],
+)
+
+setup(**setup_args)